Last season's Champions League flops, Manchester United and Celtic will seek a flying start when they meet in the Group F tie at Old Trafford.
Monaco beat Paris St Germain 2-0 and they are now third in the standings with 42 points from 23 games.
Middlesbrough beat AS Roma to reach the UEFA Cup quarterfinals for the first time
Chelsea took a five-point lead at the top of the English Premier League after beating champions Manchester United 1-0 in Sunday's show piece match. In Spain, Barcelona retained their one-point lead over Real Madrid.
The title race in Europe's top leagues remained tense at the weekend with Inter Milan losing at Napoli and Liverpool keeping the pressure on Manchester United. VfL Wolfsburg and Bayern Munich both lost in Germany and Barcelona were held at Valencia but Olympique Marseille went five points clear.
2004 Champions League finalists Monaco were eliminated 2-1 on aggregate by Swiss side Basel.
Twice former winners Benfica came from behind to beat the English side 2-1 to reach the last 16 of the tournament.\nA round-up of Wednesday's matches.
The Dutch striker scored five minutes from time to earn Manchester United a 2-1 win over Benfica in the Champions League.
A summary of Tuesday night's matches in the Champions League.
Real Madrid beat Barcelona 4-2 to cut their arch-rivals' lead at the top of the Spanish League to six points with seven matches to play.
A round-up of the weekend action in Europe's leading leagues.
The Italians drew 2-2 in Greece against Egaleo, a result which sends Middlesbrough, Villarreal and Partizan Belgrade through as the three qualifiers from Group E.
A round-up of the weekend's action from Europe's leading leagues.
A round-up of the league matches in Germany, England, Italy, Spain, France and the Netherlands
A complete round-up of the weekend action in the main European leagues.
A round-up of weekend action in the main European leagues.
A round-up of weekend action in the major European leagues.
Real Madrid face Olympique Lyon, Dynamo Kiev and Steaua Bucharest in Group E of the Champions League.
Arsenal went eight points clear at the top of the English premier league after a 2-0 win over Charlton Athletic.
A review of the weekend action in the leading European leagues.
A round-up of the weekend's action in the major European leagues.
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